Tsutomu Nakashima Selected Research

Gadolinium DTPA (Magnevist)

1/2013	Estimation of perilymph enhancement after intratympanic administration of Gd-DTPA by fast T₁-mapping with a dual flip angle 3D spoiled gradient echo sequence.
2/2011	Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.
1/2011	Visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: comparison of 2D and 3D real inversion recovery imaging.
1/2010	Estimation of gadolinium-induced T1-shortening with measurement of simple signal intensity ratio between the cochlea and brain parenchyma on 3D-FLAIR: correlation with T1 measurement by TI scout sequence.
1/2010	Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T.
1/2010	MR imaging of the cochlear modiolus after intratympanic administration of Gd-DTPA.
12/2009	Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo.
2/2009	Cutting edge of inner ear MRI.
12/2008	Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.
1/2008	Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

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Tsutomu Nakashima Research Topics

Disease

29	Meniere Disease (Menieres Disease) 01/2014 - 10/2003
28	Endolymphatic Hydrops 03/2017 - 04/2002
21	Sensorineural Hearing Loss 08/2018 - 11/2002
19	Hearing Loss (Hearing Impairment) 02/2022 - 05/2003
15	Neoplasms (Cancer) 07/2014 - 02/2003
6	Vertigo (Positional Vertigo) 12/2016 - 09/2005
6	Deafness (Deaf Mutism) 01/2012 - 11/2002
6	Hemorrhage 10/2011 - 05/2006
6	Apnea 01/2010 - 04/2006
5	Sleep Apnea Syndromes (Sleep Apnea) 09/2013 - 01/2008
5	Otitis Media with Effusion 01/2013 - 01/2007
5	Labyrinth Diseases 03/2012 - 03/2007
5	Sudden Hearing Loss (Sudden Deafness) 01/2012 - 11/2002
4	Otosclerosis 03/2017 - 06/2008
4	Obstructive Sleep Apnea 09/2012 - 12/2005
3	Carcinoma (Carcinomatosis) 07/2014 - 09/2007
3	Inflammation (Inflammations) 11/2013 - 06/2005
3	Hypertension (High Blood Pressure) 11/2013 - 04/2010
3	Otitis Media 01/2013 - 12/2003
3	Infections 01/2013 - 12/2004
3	Tinnitus 01/2013 - 05/2002
3	Nasal Obstruction 05/2009 - 12/2005
2	Pain (Aches) 11/2019 - 07/2014
2	Squamous Cell Carcinoma of Head and Neck 04/2015 - 10/2006
2	Hypopharyngeal Neoplasms 08/2014 - 05/2010
2	Head and Neck Neoplasms (Head and Neck Cancer) 01/2014 - 08/2011
2	Dyslipidemias (Dyslipidemia) 11/2013 - 09/2012
2	Paralysis (Palsy) 11/2013 - 05/2010
2	Hirschsprung Disease (Hirschsprung's Disease) 01/2012 - 07/2010
2	Pendred syndrome 06/2011 - 01/2004
2	Goiter 06/2011 - 01/2004
2	Sleepiness 01/2011 - 08/2009
2	Ototoxicity 10/2010 - 02/2003
2	Herpes Zoster Oticus (Geniculate Neuralgia) 05/2010 - 05/2007
2	Bell Palsy (Bell's Palsy) 05/2010 - 04/2007
1	Cognitive Dysfunction 02/2022
1	Gagging 11/2019
1	Plasma Cell Granuloma 07/2014
1	Surgical Wound Infection 02/2014
1	Postoperative Hemorrhage 02/2014
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2014
1	Diabetic Neuropathies (Diabetic Neuropathy) 11/2013
1	Diabetic Nephropathies (Diabetic Nephropathy) 11/2013

Drug/Important Bio-Agent (IBA)

26	GadoliniumIBA 03/2017 - 03/2007
10	Gadolinium DTPA (Magnevist)FDA Link 01/2013 - 01/2008
9	gadodiamide (Omniscan)FDA Link 03/2013 - 02/2011
6	Contrast MediaIBA 05/2013 - 01/2010
5	Gentamicins (Gentamicin)FDA LinkGeneric 12/2016 - 04/2002
5	DNA (Deoxyribonucleic Acid)IBA 05/2014 - 01/2003
5	Pepsinogen A (Pepsinogen)IBA 01/2013 - 01/2007
4	Oxygen (Dioxygen)IBA 09/2013 - 01/2007
4	gadoteridol (Prohance)FDA Link 10/2012 - 03/2010
4	Proteins (Proteins, Gene)FDA Link 08/2008 - 08/2006
3	ORALIT (ORS)IBA 11/2013 - 04/2010
3	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2013 - 04/2010
3	Folic Acid (Vitamin M)FDA LinkGeneric 06/2013 - 04/2010
3	Tyrosine (L-Tyrosine)FDA Link 03/2012 - 07/2010
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2012 - 12/2003
3	Endothelin Receptors (Endothelin Receptor)IBA 01/2012 - 07/2010
3	Cisplatin (Platino)FDA LinkGeneric 08/2011 - 02/2003
3	SteroidsIBA 08/2009 - 12/2003
3	Pharmaceutical PreparationsIBA 08/2009 - 05/2003
2	Endothelin-1 (Endothelin 1)IBA 11/2013 - 05/2009
2	AcidsIBA 10/2012 - 12/2008
2	HomocysteineIBA 03/2011 - 04/2010
2	Antiviral Agents (Antivirals)IBA 01/2011 - 04/2007
2	perchlorateIBA 09/2005 - 01/2004
2	EndotoxinsIBA 06/2005 - 06/2004
2	Antineoplastic Agents (Antineoplastics)IBA 04/2004 - 02/2003
1	Uncoupling Protein 2IBA 08/2018
1	C-Reactive ProteinIBA 07/2014
1	Analgesics (Analgesic Drugs)IBA 02/2014
1	Cefazolin (Ancef)FDA LinkGeneric 02/2014
1	Azithromycin (Zithromax)FDA LinkGeneric 02/2014
1	CytokinesIBA 01/2014
1	Biological ProductsIBA 01/2014
1	CreatinineIBA 11/2013

Therapy/Procedure

12	Therapeutics 12/2016 - 04/2002
10	Intravenous Injections 03/2017 - 01/2010
10	Intratympanic Injection 01/2012 - 01/2008
7	Lasers (Laser) 12/2013 - 05/2002
6	Intravenous Administration 02/2014 - 01/2011
5	Drug Therapy (Chemotherapy) 01/2014 - 06/2006
3	Hearing Aids (Hearing Aid) 02/2022 - 05/2008
3	Radiotherapy 08/2014 - 05/2010
3	Chemoradiotherapy 01/2014 - 05/2010
3	Nasal Surgical Procedures 05/2009 - 12/2005
2	Stapes Surgery (Stapedectomy) 03/2017 - 08/2015
2	Neck Dissection (Radical Neck Dissection) 07/2014 - 02/2006
2	Tonsillectomy 02/2014 - 03/2007
2	Continuous Positive Airway Pressure 09/2012 - 01/2011
2	Injections 01/2012 - 01/2010
2	Laryngoscopes 05/2010 - 12/2009
1	Endoscopes 11/2019
1	Decompression 12/2016
1	Induction Chemotherapy 04/2015
1	General Anesthesia 07/2014
1	Biological Therapy 05/2014
1	Oncolytic Virotherapy 05/2014
1	Oral Administration 02/2014